Treatment-Resistant Depression
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Depression Treatment Options at ReGen Advanced Infusion & Wellness Center
Ketamine-based therapies
- We specialize in ketamine infusion therapy and related approaches for mental health conditions like depression, anxiety, PTSD, as well as chronic pain conditions, mind-body syndromes, and addiction support.
- Often used for treatment-resistant depression (when standard antidepressants don’t work)
Other supportive / adjunct treatments
Depending on the clinic plan, treatment may also include:
- Ketamine Assisted Psychotherapy (KAP)
- Infusion-based wellness therapies (e.g., NAD+, nutrients) to support brain and cellular function
- Regenerative or longevity therapies: depression is multifactorial, and we have found that investigating and supporting nutritional deficiencies, chronic pain, and self-image greatly improves depressive symptoms.
When to Seek Evaluation for Depression
At ReGen, we don’t do primary depression evaluations and screenings. You should consider a professional evaluation with your primary care provider or your mental health provider if you experience:
Core symptoms (lasting ≥2 weeks)
- Persistent sadness or low mood
- Loss of interest/pleasure (anhedonia)
- Fatigue or low energy
- Sleep or appetite changes
- Difficulty concentrating
- Feelings of guilt or worthlessness
Urgent signs (seek help immediately)
- Thoughts of self-harm or suicide
- Severe functional impairment (can’t work, eat, or get out of bed)
- Sudden worsening or mood swings
If you experience these symptoms, we recommend contacting a crisis organization, such as calling or texting 988, or going to your nearest emergency department.
Situations Where Earlier Evaluation Matters:
– Symptoms don’t improve with lifestyle changes
– You’ve already tried antidepressants without success
– Depression is interfering with relationships or job performance
Understanding the Neurobiological Drivers of Depression
Depression isn’t just “low mood.” It involves multiple brain and body systems:
1. Neurotransmitter imbalance
- Dysfunction in serotonin, dopamine, and norepinephrine signaling
- Glutamate dysregulation and decreased connectivity (key to ketamine’s efficacy)
2. Brain circuit changes
- Prefrontal cortex → shown to have reduced activity which affects decision-making and control)
- Amygdala → shown to have increased activity which increases fear and negative emotions.
- Hippocampus → often shrinks with chronic depression
3. Inflammation, immune signaling, stress dysregulation
- Chronic inflammation can affect mood and cognition
- Chronic inflammation and stress lead to chronic illness and causes changes in brain chemistry and connectivity
- This may manifest as sleep disruption, impaired memory, and emotional dysregulation
4. Neuroplasticity deficits
- Depression is increasingly seen as a disorder of reduced brain adaptability
- Treatments like ketamine may work by restoring neural connections quickly
ReGen’s Approach to Depression Treatment
ReGen Advanced Infusion and Wellness offers cutting-edge options (especially ketamine) for people who haven’t improved with standard care
Find a location near you
ReGen Advanced Infusion & Wellness Center offers treatment at three convenient locations:
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