New Research on the Safety and Effectiveness of UC-MSCs (Umbilical Cord-Derived Mesenchymal Stem Cells)
A new article in Biomolecules and Biomedicine, published in December, 2025, reviews and consolidates the growing body of evidence that stem cell therapies are safe and show efficacy in clinical applications.
“Advancing Regenerative Therapies with Umbilical Cord-derived Mesenchymal Stem Cells: A Review” was recently published in the journal, Biomolecules and Biomedicine. Author Mohamed Hussein does a deep dive into published studies about the clinical application of umbilical cord-derived mesenchymal stem cells (UC-MSCs). By limiting his search to clinical trials, his article highlights the real-world applications of UC-MSC therapy.
Benefits of Umbilical Cord-derived Stem Cells
Hussein confirms that what we have been seeing in laboratory and animal studies, continues to hold true when we apply it to actual patients. He points out that umbilical cord-derived stem cells provide multiple benefits over stem cells derived from other sources (bone marrow, adipose tissue, fetal tissue). Umbilical cord-derived stem cells are harvested from healthy umbilical cords that are donated by mothers after delivery of a healthy baby by cesarean section. These tissues used to be thrown away as medical waste. Now they are making lives better.
Real Clinical Applications of Stem Cell Therapy
UC-MSCs have been used for many different clinical scenarios. There is a strong showing in medical studies that UC-MSCs have a benefit in musculoskeletal conditions like osteoarthritis and muscle injuries. They are also used in neurologic conditions, autoimmune conditions, liver conditions, and in several organ transplants to prevent rejection of the transplant.
Stem Cell Safety and Regulation
Hussein cautions that even though the safety profile for UC-MSCs in clinical use is excellent, we still don’t have the volume and standardization of clinical data that these therapies won’t carry some long-term risks.
Though he doesn’t mention it, UC-MSC therapy for most conditions has not been approved by the Federal Drug Administration (FDA). Several states, namely Utah and Florida, have allowed clinicians to advertise stem cell therapies for specific conditions as long as they prominently display the state-specific disclaimer about FDA approval.
What People Considering Stem Cell Therapy Need to Know
With all therapies, patients should be given as much information as they need to make an informed decision about treatment. Risks and benefits should be clear and the patient should be included in these discussions.
At ReGen Advanced Infusions, we encourage our patients to obtain as much information as possible about UC-MSCs. There are potential life-changing therapies available to patients, and this article summarizes and helps confirm previous studies and reviews showing stem cells are valuable treatment options for many patients.
Contact ReGen Advanced Infusion & Wellness Center for More Information
Would you like to learn more? Visit our clinical research page to find tons of information about UC-MSCs, or fill out a contact form to get in touch with one of our doctors today for more information on the benefits of regenerative medicine.